samedicino statistikis aqtualuri sakiTxebi

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1 samedicino statistikis aqtualuri sakiTxebi
marina kikviZe Tbilisi, tfdec

2 mizani ganvixiloT samedicino statistikis ZiriTadi meTodebi;
gavecnoT kvlevis Catarebis dros daSvebul Secdomebs.

3 samedicino statistika
klinikuri kvlevis Sedegad miRebul monacemTa damuSavbis meTodia; kvlevis saSualebaa da ara Sedegi; klinikuri gamocdilebis gadayvana raodenobrivi Sefasebis enaze.

4 biostatistika da klinikuri praqtika
samecniero kvlevis organizaciisa da Catarebis meTodologia samedicino literaturis swori wakiTxva

5 kvleva zedmiwevniT guldasmiT unda davgegmoT, xolo Sedegebi - sworad avxsnaT

6 klinikur monacemTa tipebi
raodenobrivi (interval data) xarisxobrivi (nominal data) rigiTi (ordinal data)

7 normaluri ganawilebis mrudi
ganawilebis tipebi normaluri ganawilebis mrudi 50 40 30 20 10 +/– 2 standartuli gadaxra +/–1 standartuli gadaxra monacemis mniSvneloba wili populaciaSi (%)

8 asimetriuli ganawilebis mrudebi
ganawilebis tipebi asimetriuli ganawilebis mrudebi moda : yvelaze xSiri maCvenebeli mediana: wertili, romlis qvemoT da zemoT ganlagebulia maCvenebelebis zustad naxevari, anu 50% (procentili). saSualo: monacemTa jami  dakvirvebaTa ricxvi

9 statistikuri meTodebi
monacemebis aRwera parametriuli (saSualo, standartuli gadaxra) araparametriuli (mediana, moda, procentilebi) hipoTezis Semowmeba

10 nulovani hipoTezis cneba
nulovani hipoTeza (Ho) niSnavs daSvebas, rom sxvaoba or Sedarebul obieqts Soris ar aRiniSneba. Ho miReba niSnavs, rom dadgenili sxvaoba SemTxveviTia; Ho ar miReba ki piriqiT – sxvaoba ar aris SemTxveviTi. Ho SecdomiT uaryofis albaTobas ew. alfa-Secdoma / α-error. Ho SecdomiT miRebis albaTobas ew. beta-Secdoma / β-error.

11 sinamdvileSi hipoTeza:
statistikuri Secdoma sinamdvileSi hipoTeza: (1) sworia (2) arasworia (1) miRebulia sworia β - Secdoma hipoTeza (2)uaryofilia α - Secdoma sworia

12 statistikuri simZlavre
simZlavre = 1 - β-Secdoma rac ufro maRalia simZlavre, miT metia mkurnalobis meTodis upiratesobis dadgenis Sansi, Tu is arsebobs. Cveulebriv sazRvraven 80% simZlavres (zogjer 90%). simZlavre matulobs sakvlevi obieqtebis raodenobis gazrdiT.

13 monacemTa analizis tipiuri Secdomebi
sistematikuri Secdoma Sansi kolinearnoba hipotezebis areva

14 sistematikuri Secdoma
sakvlevi masalis SerCevis dros daSvebuli Secdoma - mkvlevari araobieqtiuria jgufebSi subieqtebis ganawilebis dros. gazomvis dros daSvebuli Secdomebi - erT jgufSi pacientebi ukeT sazRvraven mkurnalobis Sedegebs, vidre meoreSi. placebos efeqti - dadebiTi efeqti, rodesac pacienti fiqrobs, rom mas mkurnaloben

15 monacemTa analizis tipiuri Secdomebi
Sansi - albaToba imisa, rom Sedegi miRebul iqna SemTxveviT; mag. р=0,05 niSnavs, rom SesaZlebelia erTi SemTxveviTi Sedegi 20-dan. kolinearnoba - faqtori, romelic dakavSirebulia obieqtTan da ara daavadebasTan; mag. filtvebis kiboTi daavadebulis jibeSi asanTis kolofi.

16 monacemTa analizis tipiuri Secdomebi
hipotezebis areva - faqtori, romlis zemoqmedeba ar iyo gaTvaliswinebuli hipoTezis gansazRvrisas; mag. qlorvinilis zegavlena kiboTi daavadebis riskze qimiur mrewvelobaSi momuSaveTa Soris.

17 klinikuri kvlevebis klasifikacia
observaciuli eqsperimentuli aRwerilobiTi analitikuri SemTxvevebis aRwera/Case reports SemTxvevaTa seriebis kvleva/Case series erTmomentiani kvleva gamokiTxvebi klinikuri cdebi /Clinical trials meta-analizi /Meta-analysis «SemTxveva-kontroli» /Case-control study kohortuli /Cohort study

18 kriteriumebi kvleva cvladi Oori jgufi or jgufze meti
erTi jgufi mkurnalobamde da Semdeg erTi jgufi mkurnalobis ramdenime saxe cvladebis kavSiri raodenobrivi (normaluri ganawileba*) stiudentis Student(William Gosset ) kriteriumi dispersiu;li analizi stiudentis wyvili kriteriumi ganmeorebiTi gazomvebis dispersiu;li analizi wrfivi regresia, korelacia an blend-altmanis meTodi xarisxobrivi kriteriumi x² Kmak-nimaris kriteriumi Kkokrenis kriteriumi ...koeficienti rigiTi man-uitnis Mann-Whitney kriteriumi Kkruskal-uolisis Kruskall-Wallis kriteriumi uilkoksonis Wilcoxon kriteriumi Ffridmanis kriteriumi spirmenis rangebis korelaciis koeficienti sicocxlis xangrZlivoba Ggehanis kriteriumi *Tu ganawileba asimetriulia, iyeneben analogiur araparametriul meTodebs

19 sarwmunoebis ori koncefcia
Sida sarwmunoeba internal validity ganisazRvreba imiT, Tu Catarebuli kvleviT miRebuli Sedegebi Seesabameba sinamdviles , anu is axasiaTebs mxolod avadmyofTa gamokvleul jgufs. gareTa sarwmunoeba (ganzogadoeba) external validity or generalizability ganisazRvreba imiT, Tu Catarebuli kvleviT miRebuli Sedegebi gamoyenebadia avadmyofTa sxva jgufze.

20 kompiuteruli teqnologiebi monacemTa analizisaTvis
EpiInfo SNA - Social Network Analysis SPSS — Statistical Package for the Social Science

21 Social Network Analysis (SNA)

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24 gmadlobT yuradRebisaTvis