QurAlis presents! Our CTO Hagen Cramer presented at the Oligonucleotide Chemistry & Therapeutics Europe 2023 conference. His talk was entitled, "Control Strategies of #ASO Drug Substance for Treating #ALS & #NeurodegenerativeDiseases." #precisionmedicine
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a good target for total synthesis!
MK-1084: A Macrocyclic KRAS(G12C) Inhibitor from Merck | https://lnkd.in/gm6vhQYw Merck recently disclosed the medicinal chemistry story of their clinical KRAS(G12C) compound at the ACS Spring 2024 meeting. Using Amgen’s sotorasib as a starting point, the Merck team utilized a structurally guided macrocyclization approach to maximize potency and MetID studies to inform PK optimization leading to MK-1084. Notably, this covalent macrocyclic KRAS(G12C) inhibitor is showing promise in the clinic in combination with Merck’s cornerstone PD-1 inhibitor pembrolizumab (Keytruda™). Check out the story on Drug Hunter | https://lnkd.in/gm6vhQYw You can also find our round-up of the 12 KRAS(G12C) clinical molecules to know | https://lnkd.in/g35PiZGA
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A good amount of people I speak with have not heard of us before in the U.S. but if they have it is likely related to oligonucleotides. You face many challenges with these molecules and experience can make the difference between set-backs and success. If you are currently struggling with your oligo program or you are exploring potential partners for the future, check us out! #BetterMedicineSooner #bioanalysis #CRO
We understand that given the complexity and sensitivity of oligonucleotides, it can be challenging to find the right bioanalytical partner. CMIC has seen a steady increase in Oligonucleotide drug development as new therapies are being discovered. Our team of experts are providing the best advice and options for our clients after years of experience. We have completed 400+ assays in the US, and are continuing to grow our expertise. From qualification to sample analysis, you can rest assured knowing CMIC is handling your oligonucleotide drug development needs. Reach out to the CMIC team to discuss your upcoming oligonucleotide studies: https://lnkd.in/eCvaFBKX
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Senior Technical Sales Specialist in Molecular & Synthetic Biology France - Inside Sales -Thermo Fisher Scientific
💻 On-demand webinar to help you advance oligonucleotide drug development You'll learn about the techniques for phosphoramidite synthesis, selection, and evaluation for the development of oligonucleotide drugs. The webinar discusses: ✅Optimizing phosphoramidites for oligonucleotide therapeutic development and manufacturing ✅ Identifying phosphoramidite impurities and their potential impacts on oligonucleotide therapeutics #webinar #drugdevelopment
On-Demand Webinar: Advancing Oligonucleotide Drug Development | Thermo Fisher Scientific - DE
thermofisher.com
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Principal researcher of G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences
Exploring Arbidol's Conformational Behavior in Supercritical Carbon Dioxide: Unveiling 'Opened' and 'Closed' Conformer Groups In a groundbreaking study, researchers Konstantin V. Belov, Alexey A. Dyshin, and Ilya A. Khodov have delved into the conformational intricacies of arbidol, a pharmaceutical compound renowned for its broad applications in antiviral and immunomodulatory therapies. The research, published in the journal Molecular Liquids, focuses on arbidol's behavior in a supercritical carbon dioxide solution, shedding light on the compound's various conformers. https://lnkd.in/dNuwmK43
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The Future of Longevity is Now: Groundbreaking Integration of AI/ML - Sessions showcased how advanced AI and machine learning tools are unlocking new insights into the biology of aging and enabling identification of novel longevity drug targets. Rapid Progress in Basic Aging Research - Leaders in the field presented fascinating new findings on cellular senescence, epigenetics, and other fundamental drivers of aging processes. Optimism Regarding Healthspan Extension - There was an energizing sense that research to prolong healthy human lifespan by targeting aging is advancing rapidly and producing results. Inflection Point for Aging Science - The conference made clear we have reached a tipping point where what once seemed laughable is becoming reality in extending human healthspan and longevity.
The Grand Hall of the Københavns Universitet - University of Copenhagen is about to explode and there is a long lineup. David A. Sinclair A.O., Ph.D. in the room about to present. With the wonderful Serena Poon, CN, CHC, CHN in the front row. #ARDD2023 Aging Research & Drug Discovery Meeting This is the golden age of aging research. And several pharmaceutical companies are now using aging research as a platform for discovery of blockbuster therapeutics 🙏🤗
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